Yes, one can apply for multiple IPOs with the same demat account. Investors have the option to submit multiple IPO applications using a single demat account through a process known as the 3rd Party IPO Application. This facility allows up to 5 IPO applications to be applied from one bank account, provided each applicant has their own PAN card and demat account. However, the payment for these applications can only be made through the ASBA (Application Supported by Blocked Amount) account, and UPI is not allowed for payment. This feature offers flexibility for investors to apply for IPOs for themselves, family members, and friends using one bank account.